Study

BOPRA, Brain Oxygenation during Prehospital Anesthesia, is a nationwide, investigator-driven study carried out in cooperation of FinnHEMS Research and Development Unit, university hospital districts, Lapland hospital district and several universities of applied sciences. The study explores cerebral oxygenation of patients undergoing prehospital anesthesia with a NIRS monitoring device designed especially for prehospital care.

Clinical Trials registration

Background

Securing an adequate oxygen supply to the brain is the primary aim of almost all critically ill or injured patients treated by HEMS. Adequate oxygenation of the brain is a prerequisite for the patient’s full recovery. Many therapies for this purpose are available in a prehospital setting,

Despite the variety of treatment modalities, the monitoring of oxygenation of the brain in the prehospital setting is crude, dependent on indirect measures and based on population-based evidence. Thus, we wanted to pilot using near infrared spectroscopy (NIRS), already in use with high risk patients in in-hospital operating rooms, in the prehospital critical care setting and more precisely in HEMS.

Aims

It has been proved earlier that NIRS provides information that clearly complements current patient monitoring. It could probably better guide the treatment of patients also in prehospital care. The aim of this study is to monitor patients’ cerebral oxygenation during prehospital anesthesia and to see how brain oxygenation is associated with the their subsequent recovery. The ultimate goal is to develop patient monitoring modalities and thus improve their care.

Funding

BOPRA study receives no funding from the manufacturers. It is mainly funded by FinnHEMS Research and Development Unit and it has also received some funding from Helsinki University Hospital.

Schedule

The pilot study began in May 2019 at the HEMS bases of Vantaa and Oulu. The aim of the pilot study is to ensure the feasibility of the monitoring device in a HEMS setting and to provide data for refining the research methodology and sample size determination of the following large-scale main study. A hundred study patients will be recruited during the pilot study. 

The large-scale main study is supposed to begin at all Finnish HEMS bases in November 2019. The data collection will last 1-2 years, during which 700-1300 study patients will be recruited. 

The results of the study will be published in international peer-reviewed publications in 2020-2022.  

NIRS monitoring device

The study will be carried out with a NIRS monitoring device measuring brain oxygenation with near-infrared technology. The new NIRS device is a very small combination corresponding roughly to the size of a match box and a mobile phone, which makes it easy to use in prehospital conditions.